Samuel Francis du Pont (1803-1865) was a Rear Admiral in the United States Navy and fought in the Mexican-American War and the Civil War. The collection contains letters to Joel Turrill (1794-1859) and Joseph Henry (1797-1878). The letters to Turrill are personal in content, referring to their friendship which dated back to 1845 when they both served on the U.S.S. Congress. The letter to Henry references controvery in the Senate involving Henry, likely concerning the Light-House Board.

Samuel Francis du Pont (1803-1865) was a Rear Admiral in the United States Navy and fought in the Mexican-American War and the Civil War. He was the fourth child and second surviving son of Victor Marie du Pont (1767-1827) and his wife, Gabrielle Joséphine de la Fite de Pelleport (1770-1837). The collection is a microfilmed selection of du Pont's correspondence with contemporaries, primarily Alexander Dallas Bache (1806-1867). The letters concern Civil War activities, especially the use of ironclads in naval operations.

Sophie du Pont Ford (1871-1957) was the daughter of Victor du Pont (1828-1888) and Alice Hounsfield du Pont (1833-1904) and the wife of Bruce Ford (1873-1931). The letter indicates Ford is giving a lacquered Chinese-work box to her niece, Greta du Pont Barksdale Brown (1924-2014).

Irene "Sophie" Sophie du Pont May (1900-2001) was a churchwoman, a philanthropist, and a descendant of Pierre Samuel du Pont de Nemours (1739-1817) who founded the E.I. du Pont de Nemours & Company with his son Eleuthère Irénée du Pont (1771-1834) in 1802. The E.I. du Pont de Nemours & Company is a chemical company more commonly referred to as the DuPont company. The collection consists of Sophie du Pont May's family correspondence and financial correspondence as well as correspondence between her father Irénée du Pont (1876-1963) and his older sister Louisa d'Andelot du Pont Copeland (1868-1926).

Sophie Madeleine du Pont (1810-1888) was the youngest daughter of Eleuthère Irénée du Pont (1771-1834), founder of E.I. du Pont de Nemours & Co., and Sophie Madeleine Dalmas du Pont (1775-1828), and the wife of Samuel Francis du Pont (1803-1865). The collection contains twelve letters and documents regarding the du Pont family, discussing family and church news, as well as a letter from Samuel B. Brown regarding the Brandywine Manufacturers' Sunday School.

Sophie Madeleine du Pont (1810-1888) was the youngest daughter of Eleuthère Irénée du Pont (1771-1834), founder of E.I. du Pont de Nemours & Co., and Sophie Madeleine Dalmas du Pont (1775-1828), and the wife of Samuel Francis du Pont (1803-1865). The letter to Eliza Gardner (Henderson) Jones (1826-1877) concerns family matters and the Civil War.

Sophie Madeleine du Pont (1810-1888) was the youngest daughter of Eleuthère Irénée du Pont (1771-1834), founder of E.I. du Pont de Nemours & Co., and Sophie Madeleine Dalmas du Pont (1775-1828), and the wife of Samuel Francis du Pont (1803-1865). The letter from du Pont to Lammot du Pont (1831-1884) concerns the disposal of a book of her husband's on marine artillery.

Sophie Madeleine du Pont (1810-1888) was the youngest daughter of Eleuthère Irénée du Pont (1771-1834), founder of E.I. du Pont de Nemours & Co., and Sophie Madeleine Dalmas du Pont (1775-1828), and the wife of Samuel Francis du Pont (1803-1865). In the letter to Mary Ann (Hogg) Brunot (1822-1899), du Pont thanks her for a sermon Brunot sent and reflects du Pont's concern with religious and domestic matters.

Sophie Madeleine du Pont (1810-1888) was the youngest daughter of Eleuthère Irénée du Pont (1771-1834), founder of E.I. du Pont de Nemours & Co., and Sophie Madeleine Dalmas du Pont (1775-1828), and the wife of Samuel Francis du Pont (1803-1865). The letter from du Pont to Theophilus Parsons Chandler (1807-1887) concerns her trip to White Sulphur Springs, Virginia, with her husband Eliza J. Schlatter (1809-1892).

Sophie Madeleine du Pont (1810-1888) was the youngest daughter of Eleuthère Irénée du Pont (1771-1834), founder of E.I. du Pont de Nemours & Co., and Sophie Madeleine Dalmas du Pont (1775-1828), and the wife of Samuel Francis du Pont (1803-1865). The two letters to Henry Ferris (1855-1941), a printer in Wilmington, Delaware, concern a religious tract and a subscription to the Wilmington Weekly.

Victor Marie du Pont (1767-1827) was a French diplomat. In 1794, he married Gabrielle Joséphine de La Fite de Pelleport (1770-1837), and a year later they came to the United States, where he was appointed as consul at Charleston, South Carolina. They returned to France in 1798, but came back to the United States in 1800 with their children; his father, Pierre Samuel du Pont de Nemours (1739-1817); and his younger brother, Éleuthère Irénée du Pont (1771-1834), and his family. Victor and Joséphine du Pont had five children, four surviving to adulthood: Amelia Elizabeth (1796-1869), Charles Irénée (1797-1869), Samuel Francis (1803-1865), and Julia Sophie (1806-1882). (The papers of Samuel Francis Du Pont, husband of Sophie Madeleine Du Pont, are held in Group IX of the Winterthur Manuscripts.) The collection is arranged into three series: Amelia du Pont papers, Charles Irénée du Pont and his wives' papers, and Julia (du Pont) Shubrick and her husband, Irvine Shubrick papers. The papers consist primarily of personal correspondence with family and friends.

Victorine Elizabeth du Pont (1825-1887) was the daughter of Alfred Victor du Pont (1798-1856), senior partner in E.I. du Pont de Nemours & Company, and Margaretta Elizabeth (Lammot) du Pont (1807-1898), and the wife of Peter Kemble (1825-1887). Her papers contain miscellaneous material related to the du Pont family, including bills for her trousseau, autograph album, and correspondence from her mother, daughter, and grandson.

Wilhelmina du Pont (1906-2000) was the daughter of William K. du Pont (1875-1907) and Ethel Hallock (1876-1951), a fourth generation descendent from E.I. du Pont (1771-1834). The letters are to Wilhelmina du Pont from her cousin Alice (Belin) (Mrs. Pierre S. du Pont) (1872-1944); mother Ethel (Mrs. William Kemble du Pont); cousin Alice (du Pont) (Mrs. T. Coleman du Pont) (1863-1937); and uncle Pierre S. du Pont (1870-1954).

William du Pont, Sr. (1855-1928) was an industrialist and member of the prominent du Pont family of Delaware, whose family business was the E.I. du Pont de Nemours & Company, also known as the DuPont Company which was a large manufacturer of gunpowder. He worked for the first DuPont dynamite manufacturer, Repauno Chemical Company, as secretary and treasurer (1880-1884) and after the tragic death of Lammot du Pont (1831-1884), as president (1884-1892). William du Pont, Jr. was the youngest child of du Pont, Sr. and Annie Rogers Zinn du Pont (1858-1827). Du Pont Jr. became the president of Delaware Trust Company in 1929, the youngest bank president in Wilmington at that time. In 1952, he became chairman of the board, retaining both positions until his death in 1965. The William du Pont family papers are organized into two record groups: William du Pont, Sr. papers and William du Pont, Jr. papers. The William du Pont, Sr. papers primarily encompass the years of his active business life from the early 1880s to his death in 1928. There are also some papers from his early life and after his death. The William du Pont, Jr. papers document areas of his activities predominantly concerned with land development in Wilmington, Delaware; farming, animal breeding and foxhunting in Delaware, Pennsylvania, Maryland and Virginia; and promotion of horse racing in the United States, especially in Delaware.