E.I. du Pont de Nemours & Company is a chemical company more commonly referred to as the DuPont Company. The Executive Committee became the principal body for coordinating the work of the various departments of the rapidly growing company, establishing company organizational structure and policy; approving capital expenditures and contracts; and fixing salary levels, bonuses, and other compensation. The files are arranged in six series. The "E" files are primarily service record information on members of the Executive Committee, giving some prior history of the person's career with DuPont. The "D" files are limited to organization charts, dating from 1914 to 1917. The "O" files (Operative Committee), "F" files (Finance Committee), and "X" files (Executive Committee) are primarily related to patents and licensing. Finally, materials copied by David A. Hounshell and John K. Smith for their book, Science and Corporate Strategy, are included.

DuPont Merck Pharmaceutical Company was a pharmaceutical research and manufacturing plant formed in 1991 through the joint venture of the DuPont Pharmaceutical Company and Merck & Co., a leading competitor in the pharmaceutical industry. The records consist of items taken from the files of Josephine K. Baker, clinical research coordinator. They are primarily the sort of materials issued to employees, including annual and quarterly reports and employee newsletters.