Eleuthère Irénée du Pont (1771-1834), founder of E.I. du Pont de Nemours & Co., and Sophie Madeleine Dalmas du Pont (1775-1828) had four daughters. This group of materials within the Winterthur Manuscripts collection contains the papers of the three eldest: Victorine (du Pont) Bauduy (1792-1861), Evelina (du Pont) Bidermann (1796-1863), and Eleuthera (du Pont) Smith (1806-1876), as well as their respective husbands: Ferdinand Bauduy (1791-1814), James Antoine Bidermann (1790-1865), and Thomas MacKie Smith (1809-1852). Victorine du Pont Bauduy and Eleuthera du Pont Smith were teachers at the Brandywine Manufacturers' Sunday School (BMSS), a nonsectarian school offering classes in reading, writing, arithmetic, and Bible lessons. Evelina du Pont Bidermann spent much of her adult life traveling alongside her husband and then building the Winterthur mansion in Delaware. Their papers document details about their education, social life, family, attitudes, and activities through incoming and outgoing correspondence, as well as personal papers such as diaries and account books.

Henry Belin du Pont (1898-1970) was a research engineer with General Motors and the vice president of E.I. du Pont de Nemours & Company from 1939 to 1963. This collection contains correspondence from several generations of the family from the early nineteenth through the twentieth century, including Francis Gurney Smith (1784-1873), Elizabeth (Eliza) MacKie Smith (1787-1861), Joanna Smith du Pont (1815-1876), Frances du Pont Coleman (1838-1902), Eleuthera "Ella" du Pont Bradford (1848-1906), Eleuthera Bradford du Pont (1873-1953), Alicia Bradford Maddox (1875-1920) and Phoebe George Bradford (1794-1840).

The Wilson and du Pont families were prominent families in the Wilmington, Delaware area. The papers document the daily activities of three generations of Natalies: Natalie Green Driver (Wilson)(1846-1912), Natalie Driver Wilson (du Pont)(1877-1918), and Natalie Wilson du Pont (Edmonds)(1904-1975).

Samuel Francis du Pont (1803-1865) was a Rear Admiral in the United States Navy and fought in the Mexican-American War and the Civil War. He was the fourth child and second surviving son of Victor Marie du Pont (1767-1827) and his wife, Gabrielle Joséphine de la Fite de Pelleport (1770-1837). The collection is a microfilmed copy of excerpts from du Pont's journal as a midshipman aboard the Congress.

Sophie du Pont Ford (1871-1957) was the daughter of Victor du Pont (1828-1888) and Alice Hounsfield du Pont (1833-1904) and the wife of Bruce Ford (1873-1931). Her papers consist primarily of her diaries but also include a scrapbook with news clippings relating to the DuPont Company, an address book with family birth dates, and a book with watercolor and text entitled "Life of Branch H. Giles."