E.I. du Pont de Nemours & Company was established in 1802 by Pierre Samuel du Pont de Nemours (1739-1817) and his son Éleuthère Irénée du Pont (1771-1834). This collection of more than 1250 discrete photographs depicts the landscape and buildings at or near the company's explosives manufacturing plants along Brandywine Creek near Wilmington, Delaware. Approximately 900 images depict powder yard sites, including the DuPont Experimental Station, either during the mills' final decades of operation or prior to, during, and after excavation and restoration work on the site in the 1950s and 1960s. Most of the remaining images depict the worker communities which surrounded the powder yards.

Francis Gurney du Pont (1850-1904) was the youngest son of Alexis I. du Pont (1816-1857) and Joanna Smith du Pont (1815-1876), and grandson of Éleuthère Irénée "E.I." du Pont (1771-1834), founder of E.I. du Pont de Nemours & Company, a chemical company more commonly referred to as the DuPont Company. The papers consist of du Pont's student lecture and laboratory notes; letters; technical notes and papers; records of gunpowder production; patent specifications and drawings; patent correspondence; and printed patents related to gunpowder.