E.I. du Pont de Nemours & Company is a chemical company more commonly referred to as the DuPont Company. The DuPont Building occupied an entire block bound by 10th, 11th, Orange and Market Streets and was one of the first high-rises in Wilmington, Delaware. Until early 2015 the building housed DuPont's headquarters. This small collection of files on DuPont Company history and biographies were removed from the company's downtown headquarters building prior to its move to the suburbs.

Irene Sophie du Pont (1877-1961) was a philanthropist who served as the chairperson of the Delaware Commission for the Blind for thirty years. She married her distant cousin, Irénée du Pont (1876-1963), on February 1, 1900. Their eldest daughter was Irene "Sophie" Sophie du Pont May (1900-2001). Sophie du Pont May was a churchwoman and a philanthropist. Ernest Nugent Jr. (1926-2021) was the eldest son of Sophie du Pont May and Ernest Nugent May Sr (1901-1985). This small collection consists of three sets of family papers: one belonging to Irene Sophie du Pont; another to her daughter, Sophie du Pont May; and a third to Ernest N. May Jr., Sophie du Pont May's eldest son. Both of the women's papers are arranged in two sub-series. The first is comprised of papers that were removed from each of their respective lap writing desks for preservation purposes. Irene Sophie du Pont's papers consist primarily of letters written to her between 1887 and 1898, prior to her marriage in 1900. Sophie du Pont May's papers are entirely comprised of her school materials from the Friends School in Wilmington, Delaware, dating from 1910 to 1916. The second, as well as the entirety of Ernest May Jr.'s papers, is comprised of incoming correspondence primarily from family members. Irene du Pont's letters date primarily from the 1920s, while her daughter and grandson's correspondence dates primarily from 1942 to 1945 and contains references to World War II.