E.I. du Pont de Nemours & Company is a chemical company more commonly referred to as the DuPont company. This small collections consists of five DuPont Company promotional items or giveaways, primarily related to Freon products.

The E.I. du Pont de Nemours Niagara Plant produces a number of specialty chemicals, such as polymer acetates, sodium cyanide, and methyl chloride; the plant was purchased by the DuPont Company in 1930. This small collection of Niagara Plant historical files consists of plant histories, photographs, biographical information on personnel, drawings of plant buildings, and some artifacts.

Roy J. Plunkett (1910-1994) was the discoverer of Teflon, while working as a chemist at the DuPont Company. Plunkett's laboratory notebook documents the discovery of Teflon at DuPont's Jackson Laboratory in 1938. The notebook documents the experiments that led to the effective control of the rapid and explosive polymerization of tetrafluoroethylene gas into a solid polymer.