The E.I. du Pont de Nemours Niagara Plant produces a number of specialty chemicals, such as polymer acetates, sodium cyanide, and methyl chloride; the plant was purchased by the DuPont Company in 1930. The Niagara Plant, located in Niagara Falls, New York, can be traced back to two chemical companies founded in the late nineteenth century. The first was the Niagara Electro-Chemical Company, formed in 1896, which manufactured metallic sodium. The second was Roessler & Hasslacher (R&H), which began in 1885 as a precious metals business that later developed into a specialized producer of chlorine products, hydrogen peroxide, other oxides, and metal cyanides. Both companies were very successful and understood the value of combining their companies to form even greater success. They merged in 1925 and operated the Niagara plant until 1930 when DuPont purchased their assets. The purchase ensured DuPont a steady flow of raw materials for manufacturing dyes and tetraethyllead. In addition, the R&H acquisition provided DuPont with access to numerous specialized chemicals such as sodium cyanide used in electroplating, methyl chloride for refrigerants, hydrogen peroxide for oxidizing and bleaching, formaldehyde for plastic and disinfectants, dry-cleaning agents, fumigants, insecticides, and ceramic colors.

The plant operated as the R&H Department of DuPont until 1946 when it became known as the Electrochemical Department; in 1971, it was transferred to the Industrial Chemicals Department. The plant marketed the following products: polymer acetates, chlorine products, ammonia, hydrogen peroxide, cyanides, and several other specialty chemicals. The Niagara Plant was included in the DuPont Performance Chemicals spinoff that created the Chemours Company in July 2015.