Domenico Mortellito (1906-1994) was a designer, muralist, and sculptor noted for working in plastics and other synthetic materials.

Mortellito was born on September 1, 1906, in Newark, New Jersey, and graduated from the Pratt Institute in Brooklyn in 1926. He then joined the studio of Mack, Jenny & Tyler in New York, where he was employed until 1932. This early work consisted of traditional architectural murals and ceiling decorations in both fresco and oils, including work for the Morgan Library annex. From 1932 to 1942 he operated his own studio in New York. During 1934, he did some Works Progress Administration work, but in the main was able to build a new career as a decorator of public buildings and commercial displays and expositions. The nature of this work moved Mortellito in the direction of non-traditional materials, including carved and lacquered linoleum and rubber-based paints. This phase of Mortellito's work culminated in the decoration of pavilions at the New York World's Fair, including the Food, Sports, and Fashion buildings, and the buildings of Heinz, Ford, and DuPont, the latter including the first wall decorations to be made of Lucite, Plastacele, and other plastics. In the same year he had several works in carved linoleum exhibited at the Museum of Modern Art.

Mortellito served in the Army Air Force during World War II, supervising graphic presentations to General "Hap" Arnold and his staff and designing publications. On the basis of his World's Fair work, Mortellito became a design consultant to DuPont's Advertising Department after the war, and a full-time employee in 1950. In addition to murals, decorations, magazine covers, and trade show exhibits, he also created product symbols such as "Mr. Neoprene" and "Mr. Teflon," as well as the DuPont 150th anniversary memorial now on the grounds of the Hagley Museum. From 1957 to 1979, he chaired the DuPont Color Council, a unit of the Advertising Department that promoted the use of DuPont dyes. Perhaps his largest project of this period was the DuPont Pavilion at the 1964-1965 New York World's Fair. After his retirement from DuPont, Mortellito continued to produce murals and sculptures, chiefly in synthetic materials, for both public and private installation. He died on July 31, 1994.