Science and Corporate Strategy is a scholarly history of Research and Development at the DuPont Company authored by David A. Hounshell (1950-) and John Kenly Smith (1951-). The collection consists of research files compiled by Hounshell Smith for the purpose of writing the book. Research files include copies of correspondence, articles, reports, patents, chronologies, organizational charts, and contracts from the DuPont Company from 1903 though 1980.

Irénée du Pont (1876-1963) was a chemical engineer. He began work for E.I. du Pont de Nemours & Co. in 1903 in the Construction Division of the Black Powder Operating Department. After holding several positions within the company he went on to be the president of the DuPont Company. He served in this capacity from 1919 until 1926. The collection consists of photographs related to Irénée du Pont's family, personal interests, and involvement with organizations such as the Delaware Safety Council.

The Natrona Alkali Company was incorporated to hold title to 1,600 acres of sodium carbonate deposits in Natrona County by the descendants of chemist, Lammot du Pont (1831-1884), who developed B blasting powder, using Chilean sodium nitrate and had hoped that the sodium carbonate might become a substitute for imported sodium nitrate in the manufacture of explosives, but the deposits turned out to have no commercial application. The Natrona Alkali Company records are primarily the corporate records related to a second incorporation of the company due to a clerical oversight, the materials date from 1950 to 1980, though there are some documents from the ealier company.

In the spring of 1934 the Senate's Special Committee Investigating the Munitions Industry chaired by Senator Gerald P. Nye (1892-1971) began to examine the role that the munitions manufacturers had played during the First World War. This collection consists of photographs of P. S. du Pont, Irénée du Pont, Lammot du Pont, and A. Felix du Pont testifying before the Nye Committee in September of 1934.

Irene "Sophie" Sophie du Pont May (1900-2001) was a churchwoman, a philanthropist, and a descendant of Pierre Samuel du Pont de Nemours (1739-1817) who founded the E.I. du Pont de Nemours & Company with his son Eleuthère Irénée du Pont (1771-1834) in 1802. The E.I. du Pont de Nemours & Company is a chemical company more commonly referred to as the DuPont company. The collection consists of Sophie du Pont May's family correspondence and financial correspondence as well as correspondence between her father Irénée du Pont (1876-1963) and his older sister Louisa d'Andelot du Pont Copeland (1868-1926).