E. Paul du Pont (1887-1950), the son of Francis Gurney du Pont (1850-1905) and Elise Simons du Pont (1849-1919), is best known as the manufacturer of the Du Pont automobile. He owned the house Squirrel Run Hill, the former Second Office of E.I. du Pont de Nemours & Company, and the surrounding grounds. This small collection includes papers relating to additions and alterations to Squirrel Run Hill and papers relating to the estates of his parents.

Elise Simons du Pont (1849-1919) was the wife of Francis Gurney du Pont (1850-1904), a vice president of E.I. du Pont de Nemours & Co., a chemical company more commonly referred to as the DuPont Company. The records consist of itemized household receipts, primarily from three Wilmington, Delaware grocers and one from John Wanamaker's department store in Philadelphia. The receipts give descriptions of goods and prices.

Francis Gurney du Pont (1850-1904) was the youngest son of Alexis I. du Pont (1816-1857) and Joanna Smith du Pont (1815-1876), and grandson of Éleuthère Irénée "E.I." du Pont (1771-1834), founder of E.I. du Pont de Nemours & Company, a chemical company more commonly referred to as the DuPont Company. The collection consists primarily of correspondence from du Pont to his wife, Elise Wigfall Simons (1849-1919), but include items from other family members, as well as a journal of du Pont's, manuscripts written by him, and plays and novels by Alice Simons (1849-1891).