The Du Pont family is a prominent Delawarean family descended from Pierre Samuel du Pont de Nemours (1739-1817), a French political economist, writer, publisher, and public administrator who immigrated to America with his sons, Victor Marie du Pont (1767-1827) and Eleuthère Irénée du Pont (1771-1834), in 1800. In 1802, he founded E.I. du Pont de Nemours & Company with his younger son, Eleuthère Irénée du Pont. E.I. du Pont de Nemours & Company is a chemical research and manufacturing company more commonly referred to as the DuPont Company. This small set of materials contains business and personal papers. The collection is organized into three series: Correspondence, business, and personal documents; Copies and extracts of correspondence and other documents; and Illustrative materials.

Henry du Pont (1812-1889) was an American military officer and son of Eleuthère Irénée du Pont (1771-1834), founder of E.I. du Pont de Nemours & Co., and Sophie Madeleine Dalmas du Pont (1775-1828). The collection consists of photocopied letters from Henry du Pont (1812-1889) and typescript of Pierre Samuel du Pont de Nemours (1739-1817) autobiography he wrote in 1792. The letters are from sisters Eleuthera du Pont Smith (1806-1876) and Sophie Madeleine du Pont (1810-1888), as well as William Tecumseh Sherman (1820-1891) and M. Saito of the Japanese Navy.