Eleuthère Irénée du Pont (1771-1834), founder of E.I. du Pont de Nemours & Co., and Sophie Madeleine Dalmas du Pont (1775-1828) had four daughters. This group of materials within the Winterthur Manuscripts collection contains the papers of the three eldest: Victorine (du Pont) Bauduy (1792-1861), Evelina (du Pont) Bidermann (1796-1863), and Eleuthera (du Pont) Smith (1806-1876), as well as their respective husbands: Ferdinand Bauduy (1791-1814), James Antoine Bidermann (1790-1865), and Thomas MacKie Smith (1809-1852). Victorine du Pont Bauduy and Eleuthera du Pont Smith were teachers at the Brandywine Manufacturers' Sunday School (BMSS), a nonsectarian school offering classes in reading, writing, arithmetic, and Bible lessons. Evelina du Pont Bidermann spent much of her adult life traveling alongside her husband and then building the Winterthur mansion in Delaware. Their papers document details about their education, social life, family, attitudes, and activities through incoming and outgoing correspondence, as well as personal papers such as diaries and account books.

Irene Sophie du Pont (1877-1961) was a philanthropist who served as the chairperson of the Delaware Commission for the Blind for thirty years. She married her distant cousin, Irénée du Pont (1876-1963), on February 1, 1900. Their eldest daughter was Irene "Sophie" Sophie du Pont May (1900-2001). Sophie du Pont May was a churchwoman and a philanthropist. This small collection consists of two sets of papers, one belonging to Irene Sophie du Pont and the other to her daughter, Sophie du Pont May. The papers were removed from each of their respective lap writing desks for preservation purposes. Irene Sophie du Pont's papers consist primarily of letters written to her between 1887 and 1898, prior to her marriage in 1900. Sophie du Pont May's papers are entirely comprised of her school materials from the Friends School in Wilmington, Delaware, dating from 1910 to 1916.