The Brandywine Manufacturers Sunday School (BMSS) was organized in 1817 as a non-sectarian school for the children of the local factory workers, with instruction in reading, writing, arithmetic, and religion. Éleuthère Irénée du Pont (1771-1834), founder of the DuPont Company, was one of its chief subscribers, and the school building was located on his property. Primarily generated and maintained by the du Pont women, the BMSS records include the school's constitution, and financial records such as bills, receipts, and accounts. Most of the records pertain to students with information about premiums which were given as rewards for attendance and scholarly excellence.

Eleuthère Irénée du Pont (1771-1834) was the founder of E.I. du Pont de Nemours & Company. The collection contains original love letters from du Pont to his wife, Sophie (Dalmas) du Pont (1775-1828). He writes of how much he loves his wife and misses her when away. English transcribed extracts of several letters were done by their daughter, Sophie Madeleine du Pont (1810-1888).