Caspar Wistar (1696–1752) was a German-born Philadelphia merchant and brass button maker. He also founded the first glassworks in America near Salem, New Jersey, in 1739. The single volume contains a cash book of receipts of Wistar's estate (1752-1765).

E. Paul du Pont (1887-1950), the son of Francis Gurney du Pont (1850-1905) and Elise Simons du Pont (1849-1919), is best known as the manufacturer of the Du Pont automobile. He owned the house Squirrel Run Hill, the former Second Office of E.I. du Pont de Nemours & Company, and the surrounding grounds. This small collection includes papers relating to additions and alterations to Squirrel Run Hill and papers relating to the estates of his parents.

Henry Disston & Sons, Inc. was a major manufacturer of saws and other woodworking tools and one of the largest industrial firms in Philadelphia. The Henry Disston & Sons, Inc. had a number of subsidary companies, these records contain a small number of account books from only three of the firms subsidaries. There are accounts for: the Tacony Fuel Gas Company, the Henry Disston & Sons File Company, Limited, and the Henry Disston & Sons Iron & Steel Works, and an insurance ledger from the Estate of Henry Disston.

The Hiebler family papers include documents pertaining to four generations. The bulk of the collection consists of letters written by Alfred I. du Pont to his grandsons Bayard Hiebler and Benno Hiebler, dated 1927 to 1935.

Pierre Samuel "P.S." du Pont (1870-1954) was the great-grandson of Eleuthère Irénée du Pont (1771-1834), founder of E.I. du Pont de Nemours & Company, and that company played a major role in P.S. du Pont's life. He is most well-known for developing the preeminent botanical gardens, Longwood Gardens in Kennett Square, Pennsylvania. The P. S. du Pont estate papers document the distribution of physical items from his Longwood estate in Kennett Square, Pennsylvania, in the years following his death.

Irene "Sophie" Sophie du Pont May (1900-2001) was a churchwoman, a philanthropist, and a descendant of Pierre Samuel du Pont de Nemours (1739-1817) who founded the E.I. du Pont de Nemours & Company with his son Eleuthère Irénée du Pont (1771-1834) in 1802. The E.I. du Pont de Nemours & Company is a chemical company more commonly referred to as the DuPont company. The collection consists of Sophie du Pont May's family correspondence and financial correspondence as well as correspondence between her father Irénée du Pont (1876-1963) and his older sister Louisa d'Andelot du Pont Copeland (1868-1926).