Dr. Alexis Irénée du Pont (1843-1904) was a businessman and non-practicing physician who resided in both Louisville, Kentucky, and Wilmington, Delaware. The Alexis Irénée du Pont family papers primarily consist of both outgoing and incoming correspondence from A. I. du Pont and his immediate family.

Margaretta “Meta” du Pont Coleman (1862-1938) was a descendant of Pierre Samuel du Pont de Nemours (1739-1817) who founded the E.I. du Pont de Nemours & Company with his son Eleuthère Irénée du Pont (1771-1834) in 1802. The E.I. du Pont de Nemours & Company is a chemical company more commonly referred to as the DuPont company. The Margaretta E. "Meta" du Pont Coleman Papers primarily consist of family correspondence collected by Meta Coleman.