This subseries documents General Motors Corporation, which is based in Detroit, Michigan. General Motors was founded by William C. Durant in 1908 as a holding company for Buick. The new firm immediately grew by acquiring other companies, including Oldsmobile (1908), Cadillac (1909), and Oakland (1909). Durant lost control of the company in 1910, but responded by co-founding Chevrolet Motor Car Company and by secretly buying a controlling interest in General Motors. In Durant's absence, General Motors formed GMC in 1911 by merging Rapid Motor Vehicle Company with Reliance Motor Car Company. Durant regained control of General Motors in 1916 and merged Chevrolet into it the following year.

Durant lost control of General Motors for good in 1921 and was replaced by Alfred P. Sloan. Under Sloan, the company became the largest of the American "Big Three" automakers and embarked on a period of growth that lasted several decades. Over the course of its business life, it established several new nameplates (some more successful than others) including Pontiac (1926), LaSalle (1927) Viking (1929), Marquette (1930), and Saturn (1985). General Motors also gained control of a number of domestic and foreign companies, including Vauxhall (1925), Opel (1929), Holden (1931), Saab (1990), and Hummer (1992). The firm also purchased significant interests in Isuzu (1971-Present) and Subaru (1999-2006).

General Motors encountered severe financial difficulties in the early twenty-first century, which it initially sought to address through restructuring, which included discontinuing the Oldsmobile nameplate (2004) and selling its interest in Subaru (2006). But the financial problems proved to be more than the company could overcome and General Motors filed for Chapter 11 bankruptcy in June 2009, from which it emerged a month later with the United States government as a major stakeholder. After emerging from bankruptcy, General Motors underwent considerable restructuring, which involved discontinuing the Hummer, Pontiac, and Saturn nameplates in 2010, and selling Saab that same year.

General Motors Corporation is still the largest of the American "Big Three" and is currently the largest automaker in the world. See also Buick, Cadillac, Chevrolet, Daewoo, GMC, Holden, Hummer, Isuzu (Japan), LaSalle, Marquette, Oakland, Oldsmobile, Opel (Germany), Pontiac, Saab (Sweden), Saturn, Subaru (Japan), Vauxhall (United Kingdom), and Viking.