The Charles B. McCoy papers document McCoy's tenure as president (1967-1973) and chairman of the board (1971-1974) of E.I. du Pont de Nemours & Co. The papers reflect the public role that McCoy played when he was chief executive officer at DuPont. During these years, he was active within the Business Roundtable, and the collection includes policy committee minutes, as well as correspondence. Of particular interest are records of the Labor Law Study Committee. There is also substantial correspondence reflecting McCoy's involvement with the Chamber of Commerce of the United States, the Conference Board, and the Manufacturing Chemists' Association.

Community affairs files describe the role that the DuPont Company played in easing tensions and facilitating the integration of Wilmington, Delaware, in the aftermath of the 1968 riots. The collection contains McCoy's correspondence with the Urban League, which documents the efforts that the DuPont Company made during the late 1960s and early 1970s to integrate its workforce and upgrade the positions of minority workers.

McCoy's role as a public spokesman for DuPont involved him in many of the larger public issues of the Richard Nixon (1913-1994) presidential years. The files document interchanges between DuPont and the federal government, particularly the Commerce Department and the White House, and with or about various public interest groups. Topics covered include the growing problem of inflation, wage and price controls, détente with the Soviet Union, rising Japanese competition and Far Eastern trade, increasing opposition to the Vietnam War, the emerging environmental movement, and the Ralph Nader (1934-) study of DuPont's role in the State of Delaware.