Series II contains the records of the Rayon Research Division, known as the Viscose Rayon Research Section, when it was part of the Rayon Department's Technical Division. The records detail research activities in the period from the late 1930s to the late 1950s. During this period, some of DuPont's best known and most commercially successful synthetic fibers, the "super polymers" nylon, Dacron, and Orlon, were first produced.

Sub-Series A is composed of files from the research facilities at the Spruance Plant in Richmond, Virginia. These records contain correspondence and monthly activity reports which describe progress in cutting-edge research conducted during the 1930s through the 1950s. There is also correspondence relating to administrative matters, competitive products, and end-use evaluation. Other records include files from the War Production Board. A set of rayon research patent notebooks is contained on 88 reels of microfilm.

Sub-Series B contains files from the research laboratory at the Yerkes Plant in Buffalo, New York. These records consist of research reports as well as correspondence relating to research and competitive products.