Subjects treated in the first group of letters (1789, 1800-1813) include: the French national gardens in New Jersey, 1801-1802; Jefferson's recommendation to the Secretary of War of E.I. du Pont's powder factory, 1803; Jefferson's reference to du Pont de Nemours' services to the U.S., 1803; Hamon's withdrawal of his stock from the powder company, due to personal property losses in San Domingo, 1803; Regnier's praise of Charles Parent's small lawsuit of Benjamin Mason vs. Nicholas McHenry, 1807; transfer to E. I. du Pont of Jacob Broom's share of stock in the Wilmington Library Co., 1807; Leschevin's request for information on American "fabrication” of potash, 1808; passage of bill for the protection of American manufacturers, 1811; plan for a Merino association, 1811; Mease's reference to a theft which should be prosecuted [Ewell affair], 1812; dissolution of Victor du Pont's “estate”, and its debt owed Cruger to be made good by E.I. du Pont, 1812; congratulations on the success of the cloth factory [du Pont, Bauduy & Co.], 1812; Law's request for information about a steam-powered flour mill, 1812; Ferdinand Bauduy, 1813; hydrostatic engine to replace water wheels, 1813; threat of the British to the Brandywine, 1814; arrangements for E. I. du Pont to lease Jaquett's farm, 1814; purchase for Mrs. John Warner of the one-sixth of the Brandywine Mill Seat Co. property, 1814

Subjects mentioned in the second group of letters (1814-1835, undated) include: Irvine's race horse “Bernadotte,” 1815; Jaquett's complaints of E. I. du Pont's neglect of the farm leased by Jaquett to du Pont, 1815; explosion at the powder factory, 1815; price of cotton yarns in the Glasgow market, 1815; difficulty of exchanging Delaware notes for Maryland or other Southern paper, 1815; confirmation of E.I. du Pont as a director of the Bank of the United States, 1815, 1822, 1825, 1827-1829; E.I. du Pont a board member from Delaware of the National Institution for the Promotion of Industry, 1820; Moore's machine for dressing cloth by water, 1822; drawback on foreign hemp, 1823; sample of goat “cassimere” wool from Calcutta, sent by Dr. Cooper, 1823; Eagle powder samples sent to the Secretary of War, 1824; opposition in Kent Co. Del., on the grounds of his tariff vote, to McLane's reelection, 1824; Delaware's claims against the War Department for militia expenses, 1826; death of Victor du Pont, 1827; duel of Louis Cazenove, 1827; Niles' committee to discuss the depression in U.S. wool manufacturing, 1827; E.I. and Charles I. du Pont, administrators for the Victor du Pont estate, vs. Peter Bauduy and Alexandre Deschapelles, 1827; death of Mme E. I. du Pont, 1828; return of Evelina (du Pont) Biddermann and her husband from France, 1828; Carey's extensive views on the need for a protective tariff, with some history of the problem, 1829; Courier & Enquirer's charges that E. I. du Pont influenced his workmen's votes in the last election, 1830; Poussin's trip to England, describing the King's pavilion at Brighton, 1831; cholera epidemic, 1832; serious accident to F.G. Smith, Jr.'s hand, 1833; cloth and powder orders