This series is arranged into two subseries: Business papers, and Personal papers.

The Business papers subseries illustrates the career path of a DuPont Company officer, and his role as president of the newly-formed Great Northern Manufacturing and Supply Company. The business papers include correspondence Ramsay received while working for Repauno Chemical Company, Great Northern, and DuPont. The letters primarily pertain to routine matters and subjects include the powder business, employees, competitors, customers, prices, and agents' concerns. The Great Northern correspondence also discusses strategy for selling powder to Indiana mines and dealings with local miners' unions. Additional business records include notebooks; drawings and specifications for powder magazines; records regarding the assignment of Great Northern; DuPont booklets on life insurance and pension, and a program and reports from a superintendents meeting.

The Personal papers subseries consists primarily of correspondence he received from his wife, Caroline "Lena" Canby Ramsay, prior to and after their marriage. The letters are personal and discuss social life and times in Wilmington, Delaware; literature; courtship and marriage; household administration; family life; and health. Other letters Ramsay received were from his parents, brother, friend and business colleague, Hamilton M. Barksdale, and others. There is also a letter book which contains copies of letters Ramsay wrote regarding his military service and insurance.