Series II consists of the personal papers of Charles L. Huston (1870-1951) and documents his life-long active service in the Presbyterian Church and its missionary work. Major correspondents include: China Inland Mission, Christian and Missionary Alliance, Federal Council of the Churches of Christ of America, Montrose Bible Conference Association, Moody Bible Conference, the National Armenia and India Relief Association, Philadelphia School for Christian Workers, Philadelphia School of the Bible, and the Scripture Gift Mission. Also included are records documenting Huston's work for Prohibition both locally and nationally. These papers contain Huston's correspondence with the Anti-Saloon League of America, National Reform Association, the National Temperance Bureau, the National Temperance Society, the Prohibition National Committee, the Victorian Anti-Saloon League, and the Woman's Christian Temperance Union.

Charles L. Huston was a public figure of some prominence and his correspondence includes letters of Calvin Coolidge (1923-1925) regarding Near East Relief, the World Court and the Ex-Servicemen Bonus Bill; Warren G. Harding (1922) regarding deporting Armenians; Herbert Hoover (1940) regarding Finland relief; Gifford Pinchot, Pennsylvania Governor (1923-1927 and 1931-1935); Franklin D. Roosevelt (1943) regarding "bombarding" the air to produce rain; Theodore Roosevelt (1917) regarding Huston's prohibition work; and Adm. Richard E. Byrd concerning his expedition (1931-1934).

The subject correspondence of Charles L. Huston (1888-1937) is filed by the following subjects: Chester County Home, Curran Estate, Pennsylvania Evangelical Association, Presbyterian Synods, and Temperance and Prohibition material. It also includes information on Huston's investments, including substantial information on the Belmont Iron Works of Philadelphia and the Florence Mining and Milling Company of Marysville, Utah. Subseries C is family correspondence and miscellany (1850-1946). The collection also documents Huston's professional activities (1898-1939). These files relate to his work with the American Iron and Steel Institute and the American Society of Mechanical Engineers.