Dr. Alexis Irénée du Pont (1843-1904) was a businessman and non-practicing physician who resided in both Louisville, Kentucky, and Wilmington, Delaware. He was a grandson of Éleuthère Irénée du Pont de Nemours (1771-1834), the eponymous founder of the E.I. du Pont de Nemours & Company in Wilmington, Delaware, and son of Alexis Irénée du Pont (1816-1857) and Joanna Maria Smith du Pont (1815-1876). The collection contains correspondence between Alexis I. du Pont Jr. and his mother Joanna while he was attending the Episcopal Academy in Philadelphia. In addition, there are also letters from his father and sister.