This series summarizes Sperry's experimental work and entrepreneurial interests in electrochemistry. Correspondence with Clinton P. Townsend describes the work of the Townsend laboratory and documents the business relationship that Sperry and Townsend established. The letters and technical reports trace Townsend's efforts to develop the caustic soda and white lead processes. Correspondence with E. H. Hooker of the Hooker Electrochemical Company describes the business negotiations between Sperry and Hooker, and Hooker's decision to help finance the development of the Townsend-Sperry process. The records include Sperry's and Townsend's correspondence with Leo Baekeland and Ernest LeMaire, who were assigned to supervise the construction and operation of the Niagara white lead plant for the Hooker Company.

The records document Sperry's and Townsend's attempts to develop an economical detinning process. Correspondence with William F. Dutton of the American Can Company describes operations of the detinning laboratory, as well as the business relationship that developed between Sperry and Dutton. The papers also describe the patent suit with Th. Goldschmidt & Company that eventually forced Sperry and Dutton to abandon their project.