Charles Irénée du Pont (1797-1869) operated a woolen factory at Louviers, near Wilmington, Delaware, from 1815 until his retirement in 1856. He was the eldest son of Gabrielle Joséphine de La Fite de Pelleport (1770-1837) and Victor Marie du Pont (1767-1827), a French diplomat. His family immigrated to the United States in 1800, when his father established a trading company, Victor du Pont de Nemours & Co., which went out of business in 1808. This collection consists of Charles I. du Pont's papers; five of his children's papers; and his father-in-law Nicholas Van Dyke's (1769-1826) papers regarding his first wife, Dorcas Montgomery Van Dyke (1806-1838).

Abraham Dupont (1572-1640) was the progenitor of the South Carolina branch of the Du Pont family. In France, he dealt in manufactures of brass and copper. This is a small collection of his papers and those of his immediate descendants. The documents include the earliest records still extant in the Du Pont family papers. They are important for the evidence of descent they offer and for details about the ancestors of Pierre Samuel du Pont de Nemours (1739-1817). Many relate to landed property in Rouen and in the nearby parishes of Fontaine-sous-Préaux and Roncherolles.