Francis Gurney du Pont (1850-1904) was the youngest son of Alexis I. du Pont (1816-1857) and Joanna Smith du Pont (1815-1876), and grandson of Éleuthère Irénée "E.I." du Pont (1771-1834), founder of E.I. du Pont de Nemours & Company, a chemical company more commonly referred to as the DuPont Company. The collection consists primarily of correspondence from du Pont to his wife, Elise Wigfall Simons (1849-1919), but include items from other family members, as well as a journal of du Pont's, manuscripts written by him, and plays and novels by Alice Simons (1849-1891).

Francoise Robin du Pont (1748-1841) was the second wife of Pierre Samuel du Pont de Nemours (1739-1817) a promienent French political economist, writer, publisher, and public administrator. The collection contains letters from du Pont to Baron (1757-1830) and Baronne Desmousseaux de Givre (1768-1843). The letters contain discussion of religious societies, his trip to Italy, and personal matters.

Henry Belin du Pont (1898-1970) was a research engineer with General Motors and the vice president of E.I. du Pont de Nemours & Company from 1939 to 1963. This collection contains correspondence from several generations of the family from the early nineteenth through the twentieth century, including Francis Gurney Smith (1784-1873), Elizabeth (Eliza) MacKie Smith (1787-1861), Joanna Smith du Pont (1815-1876), Frances du Pont Coleman (1838-1902), Eleuthera "Ella" du Pont Bradford (1848-1906), Eleuthera Bradford du Pont (1873-1953), Alicia Bradford Maddox (1875-1920) and Phoebe George Bradford (1794-1840).

Margaretta “Meta” du Pont Coleman (1862-1938) was a descendant of Pierre Samuel du Pont de Nemours (1739-1817) who founded the E.I. du Pont de Nemours & Company with his son Eleuthère Irénée du Pont (1771-1834) in 1802. The E.I. du Pont de Nemours & Company is a chemical company more commonly referred to as the DuPont company. The Margaretta E. "Meta" du Pont Coleman Papers primarily consist of family correspondence collected by Meta Coleman.