Alexis I. du Pont (1816-1857) was proprieter of his family business, E.I. du Pont de Nemours & Company, which began in the manufacture of gunpowder in 1802. He was the youngest child of Eleuthère Irénée du Pont (1771-1834), the founder of the DuPont Company. This collection contains thirteen photographic items, mostly portraits of Alexis I. du Pont and other du Pont family members.

Henry du Pont (1812-1889) was the second son of Eleuthère Irénée du Pont (1771-1834) and senior partner of E.I du Pont de Nemours & Company from 1850 to 1889. The collection consists of materials relating to the descendants of Henry and Louisa Gerhard du Pont. Primarily, the collection consists of portraits and other photographs of their daughters Evelina, Ellen, Louisa, Sara, Victorine, Sophie and other family members.