William Corbit Spruance (1873-1935) was an electrical engineer and Vice President in Charge of Production at E.I. du Pont de Nemours & Company. His wife, Alice Moore Lea Spruance (1876-1967), was a member of a Wilmington, Delaware, flour-milling dynasty. Spruance family miscellany contains threes letters, two regarding a forestry bill and one a thank you letter. Additionally, there are two copies of a newspaper article titled "This was the Civil War".

The Spruance family was a well-known family in Delaware. The family includes Senator Presley Spruance (1785-1863), Judge William C. Spruance (1831-1913), William Spruance (1873-1935), among many others. The collection includes material related to the genealogy of the Spruance family of Delaware, particularly correspondence from and to members of the Spruance family regarding their genealogy and the book compiled by William Spruance, The Spruance family in Delaware, 1733-1933.