Alfred Victor du Pont (1798-1856) was the eldest son of E.I. du Pont (1771-1834) and a senior partner of E.I. du Pont de Nemours & Company. The collection contains three letters he wrote to William Kemble (1795-1881), operator of the West Point Foundry and DuPont powder sales agent in New York City, about sales and shipments of gunpowder and credits.

Alfred Victor du Pont (1798-1856) was a senior partner in E.I. du Pont de Nemours & Company, a gunpowder manufacturer. This collection of papers documents Alfred V. du Pont’s business affiliations, relations with other family members, and relationship with du Pont workers. The bulk is comprised of correspondence, and the collection also includes a small number of advertising circulars.

The Du Pont descendants and allied families are the children of brothers Victor Marie du Pont (1767-1827) and Éleuthère Irénée "E.I." du Pont (1771–1834), as well as their grandchildren and relatives through marriage. Victor Marie du Pont and E.I. du Pont were the sons of Pierre Samuel du Pont de Nemours (1739-1817), a French political economist, writer, publisher, and public administrator. This collection consists of the papers of the descendants of Victor Marie and Eleuthère Irénée du Pont and members of allied families. The principal holdings are for Amelia Elizabeth du Pont (1796-1869) and Charles Irénée du Pont (1797-1869), children of Victor du Pont, and Charles's wife, Dorcas Van Dyke (1806-1838), as well as for Victorine du Pont Bauduy (1792-1861), Alfred Victor du Pont (1798-1856), and Eleuthera du Pont Smith (1806-1876), children of E.I. du Pont.

Eleuthère Irénée du Pont (1771-1834), founder of E. I. du Pont de Nemours & Co., and Sophie Madeleine Dalmas du Pont (1775-1828) had three sons: Alfred Victor du Pont (1798-1856), Henry du Pont (1812-1889), and Alexis I. du Pont (1816-1857). All three were partners in their father's company. This collection contains the papers of Alfred Victor du Pont, Henry du Pont, and Alexis I. du Pont, as well as those of their wives: Margaretta Elizabeth Lammot du Pont, Louisa Gerhard du Pont, and Joanna Maria Smith du Pont. The papers of Henry du Pont are the largest component, and reflect his business and military activities. Certain papers of each son relate to the affairs of E. I. du Pont de Nemours & Co.

E.I. du Pont de Nemours & Company is a chemical company more commonly referred to as the DuPont Company. The company was established in 1802 by Pierre Samuel du Pont de Nemours (1739-1817) and his son Éleuthère Irénée du Pont (1771-1834) for the production of gunpowder. The papers in this collection date from the lifetime of E.I. du Pont and document important aspects of the early history of the DuPont Company.

Éleuthère Irénée du Pont de Nemours (1771–1834) was a French American chemist and industrialist who founded the gunpowder manufacturer E.I. du Pont de Nemours & Company. E.I. du Pont married Sophie Dalmas du Pont (1775-1828) in 1791; the couple had eight children, one of whom died in infancy. This collection of papers includes outbound and inbound correspondence covering personal and business matters. These include personal accounts, writings and memoirs, legal documents, and miscellany, of which the majority are accounts. There are papers of the E.I. du Pont de Nemours & Co. that date from 1802 to 1850 and include correspondence (drafts, retained copies, and letters received), contracts and other legal documents, accounts, bills and receipts, checks, promissory notes, bills of exchange, drafts, and certain miscellaneous notes and memoranda.

Éleuthère Irénée du Pont de Nemours (1771–1834) was a French American chemist and industrialist who founded the gunpowder manufacturer, E.I. du Pont de Nemours and Company. E.I. du Pont married Sophie Dalmas du Pont (1775-1828) in 1791, and the couple had eight children, one of whom died in infancy. This collection primarily consists of E.I. du Pont's personal and business correspondence; writings and notes; school materials; memoranda on manufactures and tariffs; legal agreements; patents; and land surveys. Also included are Sophie Dalmas du Pont's correspondence and household account records.

Eugene du Pont Jr. (1873-1954) was a director of the E.I. du Pont de Nemours & Company from 1917 until 1954, and a great grandson of company founder, Éleuthère Irénée du Pont (1771-1834). The collection contains the personal papers of Eugene du Pont, Jr., and the records of the Kinloch Gun Club, a private shooting club which he founded. It also contains a separate collection of correspondence between his brother Alfred I. du Pont, vice president and general manager of the DuPont Company, with his assistant Frank L. Connable, which is an important source for the history of the company in the early 1900s.

Francis Gurney du Pont (1850-1904) was the youngest son of Alexis I. du Pont (1816-1857) and Joanna Smith du Pont (1815-1876), and grandson of Éleuthère Irénée "E.I." du Pont (1771-1834), founder of E.I. du Pont de Nemours & Company, a chemical company more commonly referred to as the DuPont Company. The collection contains two letter books of du Pont to F.G. Thomas (-1901) of the Iowa Powder Mills, photocopies of selected documents by Benjamin Franklin (1706-1790) on gunpowder, and on awards to John Paul Jones (1747-1792) for his victory over HMS Serapis, and letter from Samuel Courtauld (1752-1821) to Captain Joseph H. Rees (1789-1821).

Francis Gurney du Pont (1850-1904) was the youngest son of Alexis I. du Pont (1816-1857) and Joanna Smith du Pont (1815-1876), and grandson of Éleuthère Irénée "E.I." du Pont (1771-1834), founder of E.I. du Pont de Nemours & Company, a chemical company more commonly referred to as the DuPont Company. The papers of du Pont describe both his business activities at E.I. du Pont de Nemours & Company, his family life, and his activities in the Episcopal Church.

Pierre Samuel "P.S." du Pont (1870-1954) was an industrialist, entrepreneur, and philanthropist. He was president of E.I. du Pont de Nemours & Company from 1915 to 1919 and chairman of the board of directors from 1919 to 1940. P.S. du Pont was the great-grandson of Eleuthère Irénée du Pont (1771-1834), founder of E.I. du Pont de Nemours & Company, and the great-great-grandson and namesake of the French economist Pierre Samuel du Pont de Nemours (1739-1817). During the early 1920s, P.S. du Pont became an active collector of Du Pont materials, and bought several important bodies of manuscripts from French dealers. This collection consists of manuscripts he collected that are primarily concerned with Du Pont de Nemours, the Physiocrats, the French Revolution, and the antecedents of the Du Ponts and allied families in France. The collection also contains the Wilmington & Kennett Turnpike Co. records dating from 1811 to 1921 that were acquired by P.S. du Pont from 1919 to 1920 when he purchased the company's stock, widened the road, and turned over its administration to the Delaware State Highway Department.

Pierre Samuel "P.S." du Pont (1870-1954) was president of E.I. du Pont de Nemours & Co. (more commonly known as the DuPont Company or simply DuPont) from 1915 to 1919 and chairman of the board from 1919 to 1940. P.S. du Pont was the great grandson of Eleuthere Irenee du Pont (1771-1834), founder of E.I. du Pont de Nemours & Company. He was also an avid collector of documents on the early history of the du Pont family and the DuPont Company. This collection contains elements which were selected from both company and family papers. The material was lodged in du Pont's Wilmington office for a number of years prior to his death in 1954.