Francis Gurney du Pont (1850-1904) was the youngest son of Alexis I. du Pont (1816-1857) and Joanna Smith du Pont (1815-1876), and grandson of Éleuthère Irénée "E.I." du Pont (1771-1834), founder of E.I. du Pont de Nemours & Company, a chemical company more commonly referred to as the DuPont Company. The collection consists primarily of correspondence from du Pont to his wife, Elise Wigfall Simons (1849-1919), but include items from other family members, as well as a journal of du Pont's, manuscripts written by him, and plays and novels by Alice Simons (1849-1891).

Francoise Robin du Pont (1748-1841) was the second wife of Pierre Samuel du Pont de Nemours (1739-1817) a promienent French political economist, writer, publisher, and public administrator. The collection contains letters from du Pont to Baron (1757-1830) and Baronne Desmousseaux de Givre (1768-1843). The letters contain discussion of religious societies, his trip to Italy, and personal matters.

Henry Belin du Pont (1898-1970) was a research engineer with General Motors and the vice president of E.I. du Pont de Nemours & Company from 1939 to 1963. This collection contains correspondence from several generations of the family from the early nineteenth through the twentieth century, including Francis Gurney Smith (1784-1873), Elizabeth (Eliza) MacKie Smith (1787-1861), Joanna Smith du Pont (1815-1876), Frances du Pont Coleman (1838-1902), Eleuthera "Ella" du Pont Bradford (1848-1906), Eleuthera Bradford du Pont (1873-1953), Alicia Bradford Maddox (1875-1920) and Phoebe George Bradford (1794-1840).

Isabella du Pont Sharp (1882-1946) was a descendent of the founders of E.I. du Pont de Nemours & Company. The collection contains typed transcripts of letters written by Sharp to her sister, Margaretta du Pont Carpenter (1884-1973) while the Sharp family, friends, and children's nurses traveled around the world. The letters are filled with details about traveling, sightseeing, hotels, shopping, meals, and clothing.

Margaretta “Meta” du Pont Coleman (1862-1938) was a descendant of Pierre Samuel du Pont de Nemours (1739-1817) who founded the E.I. du Pont de Nemours & Company with his son Eleuthère Irénée du Pont (1771-1834) in 1802. The E.I. du Pont de Nemours & Company is a chemical company more commonly referred to as the DuPont company. The Margaretta E. "Meta" du Pont Coleman Papers primarily consist of family correspondence collected by Meta Coleman.

Pamela Cunningham Copeland (1906-2001) and Lammot du Pont Copeland (1905-1983) were active in the land conservation movement, cultural institutions (including both the Hagley and Winterthur Museums), and local civic and philanthropic work. The collection contains photographs of Pamela and Lammot du Pont Copeland and family members. Many of the pictures document the couple's various activities and philanthropic endeavors.