Amelia Elizabeth du Pont (1796-1869) was a granddaughter of Pierre Samuel du Pont de Nemours (1739-1817) founder the E.I. du Pont de Nemours & Company, a chemical research, and manufacturing company. She was the eldest child of Victor Marie du Pont (1767-1827) and Gabrielle Josephine de la Fite de Pelleport (1770-1837). The collection contains a photocopy of the act of the Senate and House of Representatives of the State of Delaware by which Amelia Elizabeth du Pont's (1796-1869) marriage to Nathaniel Perkins, alias Nathaniel H. Clifford, was dissolved and a declaration that their child Gabrielle du Pont (1813-1891) was legitimate.

Victor Marie du Pont (1767-1827) was a French diplomat. In 1794, he married Gabrielle Joséphine de La Fite de Pelleport (1770-1837), and a year later they came to the United States, where he was appointed as consul at Charleston, South Carolina. They returned to France in 1798, but came back to the United States in 1800 with their children; his father, Pierre Samuel du Pont de Nemours (1739-1817); and his younger brother, Éleuthère Irénée du Pont (1771-1834), and his family. Victor and Joséphine du Pont had five children, four surviving to adulthood: Amelia Elizabeth (1796-1869), Charles Irénée (1797-1869), Samuel Francis (1803-1865), and Julia Sophie (1806-1882). (The papers of Samuel Francis Du Pont, husband of Sophie Madeleine Du Pont, are held in Group IX of the Winterthur Manuscripts.) The collection is arranged into three series: Amelia du Pont papers, Charles Irénée du Pont and his wives' papers, and Julia (du Pont) Shubrick and her husband, Irvine Shubrick papers. The papers consist primarily of personal correspondence with family and friends.