E.I. du Pont de Nemours & Company is a chemical company more commonly referred to as the DuPont Company. The company was established in 1802 by Pierre Samuel du Pont de Nemours (1739-1817) and his son Éleuthère Irénée du Pont (1771-1834) for the production of gunpowder. The papers in this collection date from the lifetime of E.I. du Pont and document important aspects of the early history of the DuPont Company.

Eleuthère Irénée du Pont (1771-1834), with his father Pierre Samuel du Pont de Nemours (1739-1817), was the founder of E.I. du Pont de Nemours & Company. This collection includes his recipts for hotel and livery stable bills.

Elise Simons du Pont (1849-1919) was the wife of Francis Gurney du Pont (1850-1904), a vice president of E.I. du Pont de Nemours & Co., a chemical company more commonly referred to as the DuPont Company. The records consist of itemized household receipts, primarily from three Wilmington, Delaware grocers and one from John Wanamaker's department store in Philadelphia. The receipts give descriptions of goods and prices.

Samuel Francis du Pont (1803-1865) was a Rear Admiral in the United States Navy and fought in the Mexican-American War and the Civil War. The collection contains miscellany relating to du Pont, including testimonial from Union League of Philadelphia, receipt for newspaper subscription, envelopes, and a poem.