Scheiffelin & Co. was a leading pharmaceutical and liquor-importing house in New York City. The business was founded by Effingham Lawrence (1760-1800) in 1781 and taken over by his brothers-in-law, John B. Lawrence (1774-1844) and Jacob Schieffelin (1757-1865) in 1794. The firm descended through the Schieffelin family and was variously styled: Jacob Schieffelin (1799-1805); Jacob Schieffelin & Son (1805-1814); H.H. Schieffelin & Co. (1814-1849); Schieffelin Brothers & Co. (1849-1865); W.H. Schieffelin & Co. (1865-1895); and Schieffelin & Co. (post-1895). The firm was incorporated as Schieffelin & Co. on May 5, 1903.

The company was a leading importer and wholesaler of drugs and cosmetics. During Prohibition, alcohol was classed as a drug, and Schieffelin & Co. became a major importer of "medicinal" wines and brandies. Having established expertise in this line, the company remained in the liquor-importing business after repeal, serving as the American agent for foreign scotch, rum, and other wines and spirits. This eventually became the company's sole business after the company ended its pharmaceutical business in 1962. Scheiffelin & Co. was acquired by Moët-Hennessy in 1980. In 1987, Moët-Hennessy and Guinness merged Schieffelin with Somerset Importers Ltd. to create Schieffelin & Somerset as a joint venture.