Mordecai Lewis & Company (Philadelphia) was a merchant firm that owned several ships and specialized in imports of European goods, including white lead and, eventually, paint.

The firm was founded by Mordecai Lewis (1748-1799) and William Bingham (1752-1804) but grew out of firms Lewis had previously been a partner in.

In 1772, Lewis joined the firm Neave & Harman, which shortly after became Neave, Harman & Lewis. They were importers and dealers in white-lead and red-lead. They also imported from Europe a great deal of merchandise they sold.

In 1781, the company changed its name to Mordecai Lewis & Company. The company had suffered during the American Revolution due to blockades and much of their merchandise being captured as contraband of war and never reached Philadelphia.

After Lewis's death in 1799, his sons took over and formed a partnership under the name of M. & S. N. Lewis to act as selling agents for the firm. These two concerns were later consolidated under the firm name of John T. Lewis & Bros.

In 1820, the firm purchased the lead works of Joseph and John Richards and actively commenced the manufacture of white-lead and lead oxides. The company was formally incorporated in 1888, becoming known as John T. Lewis & Bros. Company, and became associated with the National Lead Company.

By 1911, the company was also manufacturing linseed oil and colors and entered the metal field, acquiring a factory in Baltimore, Maryland, where sheet lead, solder, babbitt metal, and similar metals were produced.