Hotel du Pont is a historic hotel located in Wilmington, Delaware that opened in 1913. The Hotel du Pont Company was organized on July 2, 1912, for the purpose of operating a hotel within the Du Pont Building in downtown Wilmington. Pierre S. du Pont (1870-1954), one of the architects of the reorganized DuPont Company, was president, and his chief financial assistant, John J. Raskob (1879-1950), was secretary-treasurer.

Prior to the completion of its new headquarters in 1907, E.I. du Pont de Nemours & Company had been run from offices in the Brandywine Works, about five miles west of the city. Since its reorganization in 1902, the company was growing rapidly and had begun to diversify away from its black powder heritage. Most of the other firms based in Wilmington had failed to make such a transition, and either remained small or became branch plants of new industrial combinations with plant managers as their highest local representative. As a result, the city was characterized by office buildings and civic amenities of an outdated, nineteenth century type. Thus in building a headquarters for a large modern corporation, DuPont was also obligated to provide the latest in high-class accommodations, dining and entertainment both for its own executives and those who would visit the city to do business with them.

The Hotel du Pont opened its doors to guests on January 15, 1913 with 150 guests rooms. The Hotel Company leased a section of the combined structure from the Du Pont Building Corporation. A separate subsidiary of the Building Corporation, The Play House Company, built and operated a 1300-seat theater within the same structure. Both P.S. du Pont and John J. Raskob maintained suites at the hotel and other du Pont family members resided there for various periods of time. The hotel's ballrooms and restaurants were the scene of many company and family functions. Notable features were the Gold Ballroom, added in 1918, the Green Room, and the Brandywine Room of 1941. In an effort to enhance its attractiveness. the Hotel du Pont sought out paintings of artistic merit. The majority were done by local artists or reflect local subject matter and include hundreds of original paintings by well known artists such as members of the the Wyeth family.

On January 1, 1927, an agreement was made with the Bowman-Biltmore Hotels Corporation to operate the Hotel du Pont and the name was changed to Hotel du Pont-Biltmore. This agreement was cancelled In June 1933 and the operation was reverted to the Hotel du Pont Company and the name was returned to Hotel du Pont. On June 30, 1934, The Hotel du Pont Company was dissolved, and its assets and liabilities were sold to the Du Pont Building Corporation. The Du Pont Building Corporation was dissolved in turn on September 30, 1936, and its assets transferred to E.I. du Pont de Nemours & Company. Since then, the hotel has been operated by managerial units of the DuPont Company: the Office Buildings Division (1936-1948), Office Buildings Department (1948-1953), General Services Department (1954-1971), Central Systems and Services Department (1971-1972), and General Services Department (1973-).

In 1955 the DuPont Company examined the future of the Hotel du Pont. Should the Hotel continue, be sold or closed? The company's Executive Committe authorized a study which concluded: that a first-class hotel was needed; other hotel chains were not interested in the Wilmington market; and food services were needed, not only for hotel guests, but also for company employees. As a result, a decision was made to modernize the Hotel and bring it up to date. Today the Hotel continues to serve the business, civic and social needs of the community.