This series includes personal accounts; student copy books and notes on the subjects of botany, physics, chemistry, natural history, Latin, and horticulture; botanical notes, including an essay on the culture of American corn; memoranda on the manufacture of gunpowder and the construction of the Brandywine mills; memoranda on American manufactures and the tariff; and notes on travels to Pittsburgh (1806) and Angelica, New York (1808).

Also included are papers concerning the South Brandywine Rangers (a militia unit during the War of 1812); legal agreements concerning the acquisition of property for the Delaware powder mills and the importation of Merino sheep; du Pont's shares in the Wilmington & Philadelphia Turnpike Co.; rules and regulations of the Philadelphia & Wilmington Steam Boat Co. (1829); patents and lists of lands owned by du Pont near Pittsburgh and in Virginia; estate papers of Dr. Pierre Didier; and a letter from Louis McLane regarding information from Delaware for his census of manufactures.