This series includes letters from political and business associates. Of particular note is Reed's extensive correspondence with Eisenhower, beginning in 1951 and continuing with some regularity until Eisenhower's death in 1969. The correspondence reflects their personal friendship and important political association. (See Series Five, “Scrapbooks,” for more Eisenhower correspondence.) Reed wrote personal congratulations to all Eisenhower appointees, which are filed in this series with other political correspondence. Also included in this series are letters between Reed and Dean Acheson, Averell Harriman, Jacob Javits, and Archibald MacLeish.

There are also papers on several trips Reed made as General Electric CEO in Series Four. In 1958, he traveled to the Soviet Union with other electrical industry representatives, visiting plants during a two-week period. This file includes Reed's personal notes, as well as correspondence relating to the trip.