The Natrona Alkali Company was incorporated to hold title to 1,600 acres of sodium carbonate deposits in Natrona County by the descendants of chemist, Lammot du Pont (1831-1884), who developed B blasting powder, using Chilean sodium nitrate and had hoped that the sodium carbonate might become a substitute for imported sodium nitrate in the manufacture of explosives, but the deposits turned out to have no commercial application. The Natrona Alkali Company records are primarily the corporate records related to a second incorporation of the company due to a clerical oversight, the materials date from 1950 to 1980, though there are some documents from the ealier company.

Irene "Sophie" Sophie du Pont May (1900-2001) was a churchwoman, a philanthropist, and a descendant of Pierre Samuel du Pont de Nemours (1739-1817) who founded the E.I. du Pont de Nemours & Company with his son Eleuthère Irénée du Pont (1771-1834) in 1802. The E.I. du Pont de Nemours & Company is a chemical company more commonly referred to as the DuPont company. The collection consists of Sophie du Pont May's family correspondence and financial correspondence as well as correspondence between her father Irénée du Pont (1876-1963) and his older sister Louisa d'Andelot du Pont Copeland (1868-1926).