Wallace Hume Carothers (1896-1937) was a chemist and inventor of Neoprene artificial rubber and Nylon synthetic fiber. He worked as a chemist in E.I. du Pont de Nemours & Company's Fundamental Research Program from 1928 until his death in 1937. This collection consists of photocopies of fourteen letters written by Carothers to his former college girlfriend from Missouri, Frances Gelvin Spencer, between 1929 and 1933. The nature of the letters is almost entirely personal.