David Jayne (1798-1866) purchased a drug store in Philadelphia in 1836. His patent medicine business grew quickly and he built this new building in 1850. The building was designed by American architects, William J. Johnston (1811-1849) and Thomas U. Walter (1804-1887) and was located at 242 Chestnut Street in Philadelphia, Pennsylvania. The firm of Dr. D. Jayne and Son was one of the largest patent medicine firms in the United States, and this building was "the most conspicuous building of the time" in Philadelphia. Engraved on wood and printed by William B. Gihon (dates unknown), an illustrator and engraver.