Charles Irénée du Pont (1797-1869) operated a woolen factory at Louviers, near Wilmington, Delaware, from 1815 until his retirement in 1856. He was the eldest son of Gabrielle Joséphine de La Fite de Pelleport (1770-1837) and Victor Marie du Pont (1767-1827), a French diplomat. His family immigrated to the United States in 1800, when his father established a trading company, Victor du Pont de Nemours & Co., which went out of business in 1808. This collection consists of Charles I. du Pont's papers; five of his children's papers; and his father-in-law Nicholas Van Dyke's (1769-1826) papers regarding his first wife, Dorcas Montgomery Van Dyke (1806-1838).

Gabrielle Josephine de La Fite de Pelleport (1770-1837) was the wife of Victor du Pont (1767-1827), a French American diplomat, politician, and businessman. He was the brother of Éleuthère Irénée du Pont (1771-1834), the founder of the E.I. du Pont de Nemours & Company. The account book is supposedly the household account book of du Pont and contains handwriting of various people, including her son Charles I. du Pont (1797-1869). Entries include purchases of coal, whiskey, soap, candles, and other items, as well as construction materials and tools.

In 1811, Girard's Bank was established in the former First Bank of the United States headquarters in order to maintain adequate banking facilities for Philadelphia. This manuscript lists all of the stockholders of the Girard Bank as of October 22, 1839.

These aerial photographs of the Tyler McConnell Bridge and ground views of the nearby area of Henry Clay Village, Delaware, including the Hagley Museum and Library's entrance, were commissioned by the State of Delaware Department of Transportation. The Tyler McConnell Bridge over the Brandywine River on Route 141 (Centre Road) opened in 1952. The area was documented when research began on building another bridge to replace the current two-lane bridge. There are also views of the Charles I. du Pont house.

Victor Marie du Pont (1767-1827) was a French diplomat. In 1794, he married Gabrielle Joséphine de La Fite de Pelleport (1770-1837), and a year later they came to the United States, where he was appointed as consul at Charleston, South Carolina. They returned to France in 1798, but came back to the United States in 1800 with their children; his father, Pierre Samuel du Pont de Nemours (1739-1817); and his younger brother, Éleuthère Irénée du Pont (1771-1834), and his family. Victor and Joséphine du Pont had five children, four surviving to adulthood: Amelia Elizabeth (1796-1869), Charles Irénée (1797-1869), Samuel Francis (1803-1865), and Julia Sophie (1806-1882). (The papers of Samuel Francis Du Pont, husband of Sophie Madeleine Du Pont, are held in Group IX of the Winterthur Manuscripts.) The collection is arranged into three series: Amelia du Pont papers, Charles Irénée du Pont and his wives' papers, and Julia (du Pont) Shubrick and her husband, Irvine Shubrick papers. The papers consist primarily of personal correspondence with family and friends.