The collection includes Dr. Vladimir K. Zworykin's records he created shortly after joining the research division of Radio Corporation of America (RCA) in 1929 through his formal retirement in 1954 as a vice president of RCA Laboratories, and from there through his active post-retirement career. While Zworykin is best known for his work on television during the 1920s and 1930s, the larger part of the collection consists of material documenting Zworykin’s work in medical electronics research and chairmanship of the International Institute for Medical Electronics and Biological Engineering.

Zworykin’s papers are composed of his publications, lectures, and other writings; patents and awards conferred; correspondence with domestic and international colleagues related to the span of his research from television to medical technologies; and research materials.

Photographs document Zworykin's career at RCA including work on kinescopes, the electron microscope, television, and other equipment. Audio and video materials contain a documentary of Zworykin's life and interviews about Zworykin with other RCA employees.

Ten of Zworykin's patent disclosure books (1930-1943) can be found in Record group 26.