E.I. du Pont de Nemours & Company is a chemical company more commonly referred to as the DuPont Company. The company was established in 1802 by Pierre Samuel du Pont de Nemours (1739-1817) and his son Éleuthère Irénée du Pont (1771-1834) for the production of gunpowder. The papers in this collection date from the lifetime of E.I. du Pont and document important aspects of the early history of the DuPont Company.

Eugene du Pont Jr. (1873-1954) was a director of the E.I. du Pont de Nemours & Company from 1917 until 1954, and a great grandson of company founder, Éleuthère Irénée du Pont (1771-1834). The collection contains the personal papers of Eugene du Pont, Jr., and the records of the Kinloch Gun Club, a private shooting club which he founded. It also contains a separate collection of correspondence between his brother Alfred I. du Pont, vice president and general manager of the DuPont Company, with his assistant Frank L. Connable, which is an important source for the history of the company in the early 1900s.

Pierre Samuel du Pont de Nemours (1739-1817) was a French political economist, writer, publisher, and public administrator. The collection contains a letter he wrote to Fermier General and Administrateur des Postes, offering advice on the handling of employees by Monneron and a collection of essays published by du Pont de Nemours about art exhibits in the Louvre in Paris.