E.I. du Pont de Nemours & Company was established in 1802 by Pierre Samuel du Pont de Nemours (1739-1817) and his son Éleuthère Irénée du Pont (1771-1834). In 1903, the DuPont Company's Executive Committee established the Experimental Station, a research facility located on the banks of the Brandywine River across from DuPont's first black powder works. This small collection of materials from the Experimental Station relates to the buildings, conducting of research, and to submission of reports.

Howard Ensign Simmons Jr. (1929-1997) was an industrial scientist and the Research Vice-President in the Central Research Department of the DuPont Company from 1979 until his retirement in 1991. His records document Simmons's role in overseeing the production of "Science and Corporate Stategy" by David A. Hounshell and John K. Smith, a scholarly history of Research and Development at the DuPont Company. Also included are reports on DuPont's diversification program in the late 1960s.