Several early companies, established by members of the du Pont family, operated on the Brandywine Creek in proximity to the mills of E.I. du Pont de Nemours & Co. These businesses included factories that produced tanned leather, woolen and cotton cloth, and yarns. The firms also owned properties that were used by, or sold to, other developers of mills in the region. This collection includes the papers of Du Pont, Bauduy & Company (1803-1815); Du Planty, McCall & Company (1813-1837); Brandywine Mill Seat Company (1798-1854); A. Cardon & Company (1824-1833); and Rockland Manufacturing Company (1825-1856).

Victor Marie du Pont (1767-1827) was a French diplomat who later immigrated to the United States and established various trading companies before moving to Delaware. He was the eldest son of Pierre Samuel du Pont de Nemours (1739-1817). The collection consists of correspondence, business and personal papers, and writings of Victor Marie du Pont and his wife, Gabrielle Joséphine (de la Fite de Pelleport) du Pont.